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MYP_148736
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Basic Information
Bac2I-NH2 (cyclic derivative of bactenecin)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
12 amino acids
C64H122N24O13S2
Standard
Sequence
RICRIVVIRCIR
Physicochemical Analysis
1499.94 Da
11.53
3.74
3.51
0.3117
1.12
0.35
-0.15
2.09
178.33
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
631.02
-3.86
27.0
19.0
51.0
103.0
0.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0027956 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
3-10
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa K799
16 μg/mL
MIC
PaperImproved derivatives of bactenecin, a cyclic dodecameric antimicrobial cationic peptide. Antimicrob Agents Chemother. 1999 May;43(5):1274-1276. doi: 10.1128/AAC.43.5.1274. PMID: 10223951. PMID10223951 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10223951/
RECORD: Rec_0053540 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
3-10
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli K-12
4 μg/mL
MIC
PaperImproved derivatives of bactenecin, a cyclic dodecameric antimicrobial cationic peptide. Antimicrob Agents Chemother. 1999 May;43(5):1274-1276. doi: 10.1128/AAC.43.5.1274. PMID: 10223951. PMID10223951 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10223951/
RECORD: Rec_0066456 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus epidermidis C621
8 μg/mL
MIC
PMID10223951 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10223951/
RECORD: Rec_0066969 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
3-10
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Salmonella typhimurium 14028s
8 μg/mL
MIC
PaperImproved derivatives of bactenecin, a cyclic dodecameric antimicrobial cationic peptide. Antimicrob Agents Chemother. 1999 May;43(5):1274-1276. doi: 10.1128/AAC.43.5.1274. PMID: 10223951. PMID10223951 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10223951/
RECORD: Rec_0076597 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperPatent US 6172185 B1 Evidence URLhttps://patents.google.com/patent/US6172185B1/en PatentUS 6172185 B1
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