Peptide Database

Peptide NameRC-101

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antiviral

Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV

Antiviral ▸ Anti-HIV

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition ▸ Replication inhibitor

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC74H136N28O19S6

DescriptionStandard

        GICRCICGKGICRCICGR
    

Molecular Weight1914.44 Da

Isoelectric Point (pI)8.98

Net Charge (pH 7.0)3.70

Net Charge (pH 7.4) 3.41

Charge Density (pH 7.0) 0.2055

GRAVY Index0.78

Hydrophobic Moment 0.57

Boman Index0.01

Instability Index-9.42

Aliphatic Index 86.67

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 375.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 769.74

LogP -9.15

H-bond Donors 35.0

H-bond Acceptors 29.0

Rotatable Bonds 65.0

Heavy Atoms 127.0

Ring Count 0.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0007028 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide3-16, 5-14, 7-12

Other ModsDisulfide bonds between Cys3 and Cys16,Cys5 and Cys14,Cys7 and Cys12.

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Entry inhibition

TargetHIV-1 98TZ017 | JC53-BL cells

Activity4.9 μg/mL

MethodIC50

Half-LifeMammalian: 30 h; Yeast: >20 h; E. coli: >10 h

PaperRC-101, a retrocyclin-1 analogue with enhanced activity against primary HIV type 1 isolates. | Owen SM, Rudolph DL, Wang W, Cole AM, Waring AJ, Lal RB, Lehrer RI. | AIDS Res Hum Retroviruses. 2004 Nov;20(11):1157-65. | DOI:10.1089/aid.2004.20.1157 | PMID:15588337 PMID15588337 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15588337/

RECORD: Rec_0015272 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide3-16, 5-14, 7-12

Other ModsDisulfide bonds between Cys3 and Cys16,Cys5 and Cys14,Cys7 and Cys12.

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Entry inhibition

TargetHIV-1 5157-35097 | JC53-BL cells

Activity4 μg/mL

MethodIC50

Half-LifeMammalian: 30 h; Yeast: >20 h; E. coli: >10 h

PaperRC-101, a retrocyclin-1 analogue with enhanced activity against primary HIV type 1 isolates. | Owen SM, Rudolph DL, Wang W, Cole AM, Waring AJ, Lal RB, Lehrer RI. | AIDS Res Hum Retroviruses. 2004 Nov;20(11):1157-65. | DOI:10.1089/aid.2004.20.1157 | PMID:15588337 PMID15588337 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15588337/

RECORD: Rec_0035452 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide3-16, 5-14, 7-12

Other ModsDisulfide bonds between Cys3 and Cys16,Cys5 and Cys14,Cys7 and Cys12.

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Entry inhibition

TargetHIV-1 93US151 | JC53-BL cells

Activity0.5 μg/mL

MethodIC50

Half-LifeMammalian: 30 h; Yeast: >20 h; E. coli: >10 h

PaperRC-101, a retrocyclin-1 analogue with enhanced activity against primary HIV type 1 isolates. | Owen SM, Rudolph DL, Wang W, Cole AM, Waring AJ, Lal RB, Lehrer RI. | AIDS Res Hum Retroviruses. 2004 Nov;20(11):1157-65. | DOI:10.1089/aid.2004.20.1157 | PMID:15588337 PMID15588337 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15588337/

RECORD: Rec_0050409 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide3-16, 5-14, 7-12

Other ModsDisulfide bonds between Cys3 and Cys16,Cys5 and Cys14,Cys7 and Cys12.

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Entry inhibition

TargetHIV-1 193317 | JC53-BL cells

Activity2.7 μg/mL

MethodIC50

Half-LifeMammalian: 30 h; Yeast: >20 h; E. coli: >10 h

PaperRC-101, a retrocyclin-1 analogue with enhanced activity against primary HIV type 1 isolates. | Owen SM, Rudolph DL, Wang W, Cole AM, Waring AJ, Lal RB, Lehrer RI. | AIDS Res Hum Retroviruses. 2004 Nov;20(11):1157-65. | DOI:10.1089/aid.2004.20.1157 | PMID:15588337 PMID15588337 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15588337/

RECORD: Rec_0073629 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial

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