Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length172 amino acids

Chemical FormulaC887H1371N235O245S6

DescriptionStandard

        VILMIDQVAGIDYSLVGAPQVTSQILDTPFKGEFFGRNWHSPAPFDAPPIRLPEKHDHMVYFAVSEYVFNTASRAYHQAGRMNFTIQNKHVPMDSPVRLHTSSFRTIVPRLARLYPNTELELEMSPESAPFLRFTPGNVTLMPVLDIQAFALLPTSSDRKPLFQLRVVSLIS
    

Molecular Weight19439.19 Da

Isoelectric Point (pI)7.18

Net Charge (pH 7.0)0.28

Net Charge (pH 7.4) -0.27

Charge Density (pH 7.0) 0.0016

GRAVY Index-0.04

Hydrophobic Moment 0.76

Boman Index0.09

Instability Index49.61

Aliphatic Index 89.53

Aromaticity 0.1047

Extinction Coeff. Reduced 12950.00

Extinction Coeff. Oxidized 12950.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7569.18

LogP -75.38

H-bond Donors 257.0

H-bond Acceptors 257.0

Rotatable Bonds 612.0

Heavy Atoms 1373.0

Ring Count 42.0

Amide Bonds 184.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0390361 VERIFIED: NO

Provenance & Taxonomy

OrganismAiluropoda melanoleuca [Animal]

Tax ID9646

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence