Peptide Database

Peptide NameEndothelin-2

Function Ontology

Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide

Cardiovascular ▸ Vascular tone modulation ▸ Vasoconstrictor activity

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length79 amino acids

Chemical FormulaC376H622N132O111S4

DescriptionStandard

        PEQTAPYGLGNPPRRRRRSLPRRCQCSSARDPSCATFCLRRPWTEARAVPSRKSPADVFQTGKTGATRGELLQRLRDIS
    

Molecular Weight8896.04 Da

Isoelectric Point (pI)11.42

Net Charge (pH 7.0)10.93

Net Charge (pH 7.4) 10.80

Charge Density (pH 7.0) 0.1383

GRAVY Index-0.99

Hydrophobic Moment 0.58

Boman Index-0.37

Instability Index97.08

Aliphatic Index 50.76

Aromaticity 0.0506

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7240.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3967.61

LogP -52.11

H-bond Donors 149.0

H-bond Acceptors 126.0

Rotatable Bonds 287.0

Heavy Atoms 623.0

Ring Count 14.0

Amide Bonds 83.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0052570 VERIFIED: NO

Provenance & Taxonomy

OrganismMacaca fascicularis [Animal]

FamilyEndothelin

Tax ID9541

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Vasoactive Vasoconstrictor

Half-LifeMammalian: >20 hour; Yeast: >20 hour; E. coli: ?

RECORD: Rec_0236331 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0313062 VERIFIED: NO

Provenance & Taxonomy

OrganismMacaca fascicularis [Animal]

FamilyEndothelin/sarafotoxin

Tax ID9541

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide24-38; 26-34

Bio-Activity Profile

Function

Vasoactive Hormone