Peptide Database

Peptide NameEKL3C

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Standard StatusStandard

Sequence Length40 amino acids

Chemical FormulaC220H337N47O69S2

DescriptionStandard

        LDLEYEMKKLEEAIKKLEESYIDLKELGTYEYYVKWGSGC
    

Molecular Weight4808.43 Da

Isoelectric Point (pI)4.57

Net Charge (pH 7.0)-4.24

Net Charge (pH 7.4) -4.48

Charge Density (pH 7.0) -0.1059

GRAVY Index-0.68

Hydrophobic Moment 0.75

Boman Index-0.05

Instability Index16.25

Aliphatic Index 87.75

Aromaticity 0.1500

Extinction Coeff. Reduced 12950.00

Extinction Coeff. Oxidized 12950.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1904.97

LogP -9.60

H-bond Donors 67.0

H-bond Acceptors 67.0

Rotatable Bonds 167.0

Heavy Atoms 338.0

Ring Count 7.0

Amide Bonds 39.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0194511 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyHR2 fusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermNone

C-TermChol

Other ModsChol

Bio-Activity Profile

Function

Antiviral Anti-SARS-CoV-2 Fusion inhibition

TargetSARS-CoV-2 | Caco-2 cells

Activity0.892±0.069 μM

MethodIC50

Half-LifeMammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min

PaperA highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases. | Zhou J, Xu W, Liu Z, Wang C, Xia S, Lan Q, Cai Y, Su S, Pu J, Xing L, Xie Y, Lu L, Jiang S, Wang Q. | Acta Pharm Sin B. 2021 Aug 2. | DOI:10.1016/j.apsb.2021.07.026 | PMID:34367893 PMID34367893 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34367893/

RECORD: Rec_0241617 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyHR2 fusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermNone

C-TermChol

Other ModsChol

Bio-Activity Profile

Function

Antiviral Fusion inhibition

Targetinhibition of cell-cell fusion

Activity0.045±0.004 μM

MethodIC50

Half-LifeMammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min

PaperA highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases. | Zhou J, Xu W, Liu Z, Wang C, Xia S, Lan Q, Cai Y, Su S, Pu J, Xing L, Xie Y, Lu L, Jiang S, Wang Q. | Acta Pharm Sin B. 2021 Aug 2. | DOI:10.1016/j.apsb.2021.07.026 | PMID:34367893 PMID34367893 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34367893/

RECORD: Rec_0347579 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermChol

Bio-Activity Profile

Function

Antimicrobial Anti-SARS-CoV-2

TargetInhibition of Pseudovirus(PsV) infection in Caco-2 cells

Activity0.892±0.069 μM

MethodIC50

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