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MYP_148479
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Basic Information
EKL3C
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Standard
40 amino acids
C220H337N47O69S2
Standard
Sequence
LDLEYEMKKLEEAIKKLEESYIDLKELGTYEYYVKWGSGC
Physicochemical Analysis
4808.43 Da
4.57
-4.24
-4.48
-0.1059
-0.68
0.75
-0.05
16.25
87.75
0.1500
12950.00
12950.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1904.97
-9.60
67.0
67.0
167.0
338.0
7.0
39.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0058350 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
Cholesterol conjugation
C-terminal cholesterol conjugation
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Fusion inhibition
SARS-CoV-2 pseudovirus; 293T/ACE2 cells
1.176±1.23 μM
IC50 (pseudovirus entry inhibition)
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperA highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases. | Zhou J, Xu W, Liu Z, Wang C, Xia S, Lan Q, Cai Y, Su S, Pu J, Xing L, Xie Y, Lu L, Jiang S, Wang Q. | Acta Pharm Sin B. 2021 Aug 2. | DOI:10.1016/j.apsb.2021.07.026 | PMID:34367893 PMID34367893 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34367893/
RECORD: Rec_0065011 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
Cholesterol conjugation
C-terminal cholesterol conjugation
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Fusion inhibition
SARS-CoV-2 pseudovirus; Huh-7 cells
0.127±0.293 μM
IC50 (pseudovirus entry inhibition)
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperA highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases. | Zhou J, Xu W, Liu Z, Wang C, Xia S, Lan Q, Cai Y, Su S, Pu J, Xing L, Xie Y, Lu L, Jiang S, Wang Q. | Acta Pharm Sin B. 2021 Aug 2. | DOI:10.1016/j.apsb.2021.07.026 | PMID:34367893 PMID34367893 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34367893/
RECORD: Rec_0109745 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Cholesterol conjugation
C-terminal cholesterol conjugation
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
SARS-CoV-2 spike-mediated cell-cell fusion
0.045±0.004 μM
IC50 (cell-cell fusion inhibition)
PaperA highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases PMID34367893 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34367893/
RECORD: Rec_0138380 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Cholesterol conjugation
C-terminal cholesterol conjugation
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
SARS-CoV-2 pseudovirus; Huh-7 cells
0.127±0.293 μM
IC50 (pseudovirus entry inhibition)
PaperA highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases PMID34367893 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34367893/
RECORD: Rec_0187271 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Cholesterol conjugation
C-terminal cholesterol conjugation
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2
SARS-CoV-2 pseudovirus; 293T/ACE2 cells
1.176±1.23 μM
IC50 (pseudovirus entry inhibition)
PaperA highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases PMID34367893 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34367893/
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