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MYP_148410
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Basic Information
Aureocin A53 (AucA)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
51 amino acids
C291H447N69O65S
Standard
Sequence
MSWLNFLKYIAKYGKKAVSAAWKYKGKVLEWLNVGPTLEWVWQKLKKIAGL
Physicochemical Analysis
5984.15 Da
10.07
7.49
7.25
0.1469
-0.08
0.72
0.14
-3.89
101.37
0.1765
31970.00
31970.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2173.93
-6.33
77.0
74.0
199.0
426.0
15.0
53.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0092521 VERIFIED: YES
Provenance & Taxonomy
Staphylococcus aureus [Bacterium]
Bacteriocin
1280
Structure & Mods
ribosomally encoded bacteriocin peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Bacteriocin Anti-Gram-positive Non-hemolytic
Listeria monocytogenes
PMID12054867 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12054867/
RECORD: Rec_0115525 VERIFIED: NO
Provenance & Taxonomy
Staphylococcus aureus [Bacterium]; Bacteria [Bacterium]
2; 2
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0143606 VERIFIED: YES
Provenance & Taxonomy
Staphylococcus aureus A53 [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Lactococcus lactis ATCC 19257
0.25 μM
MIC
PMID26771761 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26771761/
RECORD: Rec_0158452 VERIFIED: YES
Provenance & Taxonomy
Staphylococcus aureus [Bacterium]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Formylation
Bio-Activity Profile
Antimicrobial Antibacterial Host defense
PaperPDB 2N8O structural record; NMR; chain A; residues 1-51
RECORD: Rec_0196130 VERIFIED: YES
Provenance & Taxonomy
Staphylococcus aureus A53 [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Enterococcus faecium BFE900
16 μM
MIC
PMID26771761 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26771761/
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