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MYP_148346
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Basic Information
Aurein-1.2 [I5A]
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
13 amino acids
C68H107N15O19
Standard
Sequence
GLFDAIKKIAESF
Physicochemical Analysis
1438.67 Da
6.07
-0.24
-0.45
-0.0183
0.46
0.70
0.24
20.48
105.38
0.1538
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
559.39
-2.90
19.0
19.0
49.0
102.0
2.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0250046 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa ATCC 9027
512 μg/mL
MIC
Fetal bovine serum: 37℃，in fetal bovine serum, 71% remaining after 6 h
PaperMigoń D, Jaśkiewicz M, Neubauer D, Bauer M, Sikorska E, Kamysz E, Kamysz W. Alanine Scanning Studies of the Antimicrobial Peptide Aurein 1.2. Probiotics Antimicrob Proteins. 2019 Sep;11(3):1042-1054. PMID:30569430 https://pubmed.ncbi.nlm.nih.gov/30569430/ PMID30569430 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30569430/
RECORD: Rec_0300411 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Enterococcus faecalis PCM 2673
128 μg/mL
MIC
PMID30569430 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30569430/
RECORD: Rec_0346574 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans ATCC 10231
256 μg/mL
MIC
PMID30569430 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30569430/
RECORD: Rec_0366664 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli ATCC 25922
256 μg/mL
MIC
Fetal bovine serum: 37℃，in fetal bovine serum, 71% remaining after 6 h
PaperMigoń D, Jaśkiewicz M, Neubauer D, Bauer M, Sikorska E, Kamysz E, Kamysz W. Alanine Scanning Studies of the Antimicrobial Peptide Aurein 1.2. Probiotics Antimicrob Proteins. 2019 Sep;11(3):1042-1054. PMID:30569430 https://pubmed.ncbi.nlm.nih.gov/30569430/ PMID30569430 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30569430/
RECORD: Rec_0372041 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hemolytic
hRBC
256 μg/mL
Hemolysis
PMID30569430 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30569430/
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