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MYP_148294
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Basic Information
CA-MA-P
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
18 amino acids
C115H180N28O20
Standard
Sequence
KWKLFKKIPKFLHSAKKF
Physicochemical Analysis
2274.84 Da
10.78
6.84
6.58
0.3800
-0.64
0.82
-0.14
-9.94
70.56
0.2222
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
796.07
-0.38
28.0
28.0
79.0
163.0
7.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0165218 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
CA-MA / CA-ME / cecropin-magainin hybrid
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer
Jurkat
20.0 μM
IC50 / MTT-MTS assay
PaperPMID 10675500; CA-MA2 activity against leukemia cells PMID10675500 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10675500/
RECORD: Rec_0173373 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Antibacterial Toxic Antimicrobial Hemolytic
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
RECORD: Rec_0192063 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
CA-MA / CA-ME / cecropin-magainin hybrid
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer
MDA-MB-361
28.0 μM
IC50 / MTT-MTS assay
PaperPMID 10675500; CA-MA2 activity against breast cancer cells PMID10675500 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10675500/
RECORD: Rec_0215874 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cecropin A-Magainin 2 hinge-modified peptides
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Antimicrobial
Jurkat (blood cancer)
20 μM
IC50
PaperEffects of the hinge region of cecropin A(1-8)-magainin 2(1-12), a synthetic antimicrobial peptide, on liposomes, bacterial and tumor cells | https://pubmed.ncbi.nlm.nih.gov/10675500/ PMID10675500 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10675500/
RECORD: Rec_0221983 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cecropin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Cytotoxic
A-549
25 μM
IC50
PMID10675500 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10675500/
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