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MYP_148177
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Basic Information
Env4-4
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Standard
14 amino acids
C94H138N18O18S
Standard
Sequence
TNWLWYIKIFIMIV
Physicochemical Analysis
1840.28 Da
8.26
0.40
0.20
0.0283
1.39
0.29
0.65
-1.32
160.00
0.2857
12490.00
12490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
582.77
3.36
21.0
20.0
56.0
131.0
6.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0177335 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Replication inhibition
HIV-1
1.9 μM
IC50
Mammalian: 7.2 h; Yeast: >20 h; E. coli: >10 h
PaperPeptide HIV-1 integrase inhibitors from HIV-1 gene products. | Suzuki S, Urano E, Hashimoto C, Tsutsumi H, Nakahara T, Tanaka T, Nakanishi Y, Maddali K, Han Y, Hamatake M, Miyauchi K, Pommier Y, Beutler JA, Sugiura W, Fuji H, Hoshino T, Itotani K, Nomura W, Narumi T, Yamamoto N, Komano JA, Tamamura H. | J Med Chem. 2010 Jul 22;53(14):5356-60. | DOI:10.1021/jm1003528 | PMID:20586421 PMID20586421 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20586421/
RECORD: Rec_0211395 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PMID20586421 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20586421/
RECORD: Rec_0336219 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:inhibition of strand transfer catalyzed by integrase
1.9 μM
IC50
PMID20586421 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20586421/