Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length193 amino acids

Chemical FormulaC958H1511N269O256S9

DescriptionStandard

        PMALATEHEPMLLLAITEFVANSAAFTYFAAGALQRNISSDMLPRRFPLQLKTKSMGLFSPQLQERYPDHPMELHLSARRQPRLSCRPDALHGALFSSAEAFVVLPNATRVPAFLLNIDANVTGKPIFTRNRLGGTVSLKGPACAAAPSALPHARLRGLSFPQVKRLENLLKFALWLFGVPWANSECCPHSVP
    

Molecular Weight21181.48 Da

Isoelectric Point (pI)9.87

Net Charge (pH 7.0)8.46

Net Charge (pH 7.4) 8.01

Charge Density (pH 7.0) 0.0438

GRAVY Index0.04

Hydrophobic Moment 0.69

Boman Index0.09

Instability Index55.82

Aliphatic Index 91.14

Aromaticity 0.0829

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 14230.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 8241.07

LogP -98.57

H-bond Donors 286.0

H-bond Acceptors 279.0

Rotatable Bonds 671.0

Heavy Atoms 1492.0

Ring Count 43.0

Amide Bonds 206.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0042417 VERIFIED: NO

Provenance & Taxonomy

OrganismCepphus grylle (Black guillemot) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria