Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length502 amino acids

Chemical FormulaC2519H4036N656O710S20

DescriptionStandard

        MVSFTQCCCQLASRQFKHPDRKRPSIGTSQQFKIIVLEMMFLWCVLVLVNLVSVATDTNAGVKVRLTQKGLEYGRQIAIASIQQKLRTIQLQDISGTERVKAVGKVQYSFTGLQVVNLGLPKSALRLVPGTGVMLSIDNVYINLRGNWRVKYFRFIRNSGSFDLSVNELTISTTIVITSDNTGRPMVSVKTCAATVGSVKVKFHGGASWLYNLFRSFINKALRNALQKKICPLVIRSIADTNPHLKTLNGDMINYVLITVLAKVDQYAEIEYSMVGSPVISNTFIDLGLKGEFYNIGQHEEPPFSPKPFSLPTQDTKMLYFGVSAFSINSAGFVYQTAGVLRLSITDDMIGKMYPDLMVKLLVETVKEPLVTFEPNNMTVQASSTVTAYAIQPNSTLSPLFVLNLEGSVSAHIYVTELKLAGNVTLNKFKMSVAESYVGPFQVAFLDTIFTVVLRVAVLPLVNARLREGFPLPAIGKMQLVNSQLQVLKDYLLIGTDVQFNG
    

Molecular Weight55512.26 Da

Isoelectric Point (pI)9.48

Net Charge (pH 7.0)15.90

Net Charge (pH 7.4) 15.23

Charge Density (pH 7.0) 0.0317

GRAVY Index0.22

Hydrophobic Moment 0.74

Boman Index0.14

Instability Index29.94

Aliphatic Index 105.72

Aromaticity 0.0896

Extinction Coeff. Reduced 40340.00

Extinction Coeff. Oxidized 40715.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0200883 VERIFIED: NO

Provenance & Taxonomy

OrganismLabeo rohita [Bacterium]

FamilyBPI

Tax ID84645

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence