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MYP_148047
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Basic Information
L-19
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
not Standard
24 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
RXRRXRIKILFQNRRMKWKKCXXX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0191631 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
unspecified non-canonical residue at 2,5; ornithine at 22; non-canonical residue code at 23; non-canonical residue code at 24; peptide is the all-L and all-D form, respectively, lower case letters denote D form. suffix m = conjugate containing a control PNA with two mismatched (interchanged) nucleobases, X = 6-aminohexanoic acid = H2N-(CH2)5COOH residue, Anti-acpP: B= PNA2301 = H-CTCATACTCT-NH2, Mismatch: J = PNA3961 = H-CTCTTACACT-NH2, O = Mal= polar maleimide linker, Z = eg1= Ethylene glycol moeity
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC 29213
64 μg/mL
MIC
PMID30807888 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30807888/
RECORD: Rec_0193722 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
unspecified non-canonical residue at 2,5; ornithine at 22; non-canonical residue code at 23; non-canonical residue code at 24; peptide is the all-L and all-D form, respectively, lower case letters denote D form. suffix m = conjugate containing a control PNA with two mismatched (interchanged) nucleobases, X = 6-aminohexanoic acid = H2N-(CH2)5COOH residue, Anti-acpP: B= PNA2301 = H-CTCATACTCT-NH2, Mismatch: J = PNA3961 = H-CTCTTACACT-NH2, O = Mal= polar maleimide linker, Z = eg1= Ethylene glycol moeity
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli NMI 3548/14
8 μg/mL
MIC
PMID30807888 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30807888/
RECORD: Rec_0201561 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 2,5; ornithine at 22; non-canonical residue code at 23; non-canonical residue code at 24; peptide is the all-L and all-D form, respectively, lower case letters denote D form. suffix m = conjugate containing a control PNA with two mismatched (interchanged) nucleobases, X = 6-aminohexanoic acid = H2N-(CH2)5COOH residue, Anti-acpP: B= PNA2301 = H-CTCATACTCT-NH2, Mismatch: J = PNA3961 = H-CTCTTACACT-NH2, O = Mal= polar maleimide linker, Z = eg1= Ethylene glycol moeity
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Klebsiella pneumoniae NMI 3081/09
8-16 μg/mL
MIC
PMID30807888 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30807888/
RECORD: Rec_0225221 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 2,5; ornithine at 22; non-canonical residue code at 23; non-canonical residue code at 24; peptide is the all-L and all-D form, respectively, lower case letters denote D form. suffix m = conjugate containing a control PNA with two mismatched (interchanged) nucleobases, X = 6-aminohexanoic acid = H2N-(CH2)5COOH residue, Anti-acpP: B= PNA2301 = H-CTCATACTCT-NH2, Mismatch: J = PNA3961 = H-CTCTTACACT-NH2, O = Mal= polar maleimide linker, Z = eg1= Ethylene glycol moeity
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli sbmA
32 μg/mL
MIC
PMID30807888 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30807888/
RECORD: Rec_0240648 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
unspecified non-canonical residue at 2,5; ornithine at 22; non-canonical residue code at 23; non-canonical residue code at 24; peptide is the all-L and all-D form, respectively, lower case letters denote D form. suffix m = conjugate containing a control PNA with two mismatched (interchanged) nucleobases, X = 6-aminohexanoic acid = H2N-(CH2)5COOH residue, Anti-acpP: B= PNA2301 = H-CTCATACTCT-NH2, Mismatch: J = PNA3961 = H-CTCTTACACT-NH2, O = Mal= polar maleimide linker, Z = eg1= Ethylene glycol moeity
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli NMI 3898/15
32 μg/mL
MIC
PMID30807888 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30807888/
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