Peptide Database

Peptide NameCtry2459-H2 (Ctry2459 peptide derivative, His-rich)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antiviral

Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV

Antiviral ▸ Virucidal activity

Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxic

Venom / Toxin ▸ General toxin ▸ Toxicity

Standard StatusStandard

Sequence Length9 amino acids

Chemical FormulaC59H79N13O10

DescriptionStandard

        FLGFLHHLF
    

Molecular Weight1130.34 Da

Isoelectric Point (pI)6.92

Net Charge (pH 7.0)-0.07

Net Charge (pH 7.4) -0.37

Charge Density (pH 7.0) -0.0073

GRAVY Index1.44

Hydrophobic Moment 0.44

Boman Index0.71

Instability Index8.89

Aliphatic Index 130.00

Aromaticity 0.3333

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 353.48

LogP 1.71

H-bond Donors 12.0

H-bond Acceptors 12.0

Rotatable Bonds 33.0

Heavy Atoms 82.0

Ring Count 5.0

Amide Bonds 8.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0417339 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-HCV Infection inhibition

TargetHepatitis C virus | 7.5.1 cells

Activity0.9554 μM

MethodEC50

Half-LifeMammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min

PaperDesign of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus. | Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z. | Biomaterials. 2013 Apr;34(13):3511-22. | DOI:10.1016/j.biomaterials.2013.01.075 | PMID:23415044 PMID23415044 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23415044/

FIRST PREV 1 2 3 4

Showing 1 records on this page Ã‚Â· Page 4 of 4