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MYP_147978
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Basic Information
Ctry2459-H2 (Ctry2459 peptide derivative, His-rich)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV
Antiviral ▸ Virucidal activity
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
9 amino acids
C59H79N13O10
Standard
Sequence
FLGFLHHLF
Physicochemical Analysis
1130.34 Da
6.92
-0.07
-0.37
-0.0073
1.44
0.44
0.71
8.89
130.00
0.3333
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
353.48
1.71
12.0
12.0
33.0
82.0
5.0
8.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0251237 VERIFIED: NO
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PaperDesign of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus. Biomaterials. 2013 Feb 13;34(13):3511-3522. doi: 10.1016/j.biomaterials.2013.01.075. PMID: 23415044. PMID23415044 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23415044/
RECORD: Rec_0280823 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Hepatitis C virus JFH-1; Huh7.5.1 cells
1.08 μg/mL
HCV infection inhibition (EC50)
PMID23415044 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23415044/
RECORD: Rec_0372761 VERIFIED: YES
Provenance & Taxonomy
Scorpiones [Animal]
Scorpion venom peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Virucidal
Hepatitis C virus JFH-1; Huh7.5.1 cells
0.95545 μM
HCV infection inhibition (EC50)
PaperDesign of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus. | Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z. | Biomaterials. 2013 | PMID:23415044 PMID23415044 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23415044/
RECORD: Rec_0417339 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-HCV Infection inhibition
Hepatitis C virus JFH-1; Huh7.5.1 cells
0.9554 μM
HCV infection inhibition (EC50)
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperDesign of histidine-rich peptides with enhanced bioavailability and inhibitory activity against hepatitis C virus. | Hong W, Zhang R, Di Z, He Y, Zhao Z, Hu J, Wu Y, Li W, Cao Z. | Biomaterials. 2013 Apr;34(13):3511-22. | DOI:10.1016/j.biomaterials.2013.01.075 | PMID:23415044 PMID23415044 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23415044/
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