Peptide Database

Peptide NameNatriuretic peptide PaNP-c

Function Ontology

Cardiovascular

Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide

Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Hormonal / Endocrine ▸ Hormone peptide

Membrane / Ion-channel modulation ▸ Ion channel modulation

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length35 amino acids

Chemical FormulaC145H235N45O48S3

DescriptionStandard

        SGSKTAEIGDGCFGVPIDHIGSTSGMGCGRPRPKP
    

Molecular Weight3472.88 Da

Isoelectric Point (pI)7.81

Net Charge (pH 7.0)0.53

Net Charge (pH 7.4) 0.24

Charge Density (pH 7.0) 0.0152

GRAVY Index-0.44

Hydrophobic Moment 0.34

Boman Index0.02

Instability Index39.97

Aliphatic Index 44.57

Aromaticity 0.0286

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1455.36

LogP -21.08

H-bond Donors 52.0

H-bond Acceptors 53.0

Rotatable Bonds 110.0

Heavy Atoms 241.0

Ring Count 6.0

Amide Bonds 34.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0103829 VERIFIED: YES

Provenance & Taxonomy

OrganismPseudechis australis [Animal]

FamilyNatriuretic peptide PaNP

Tax ID8670

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide12-28

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Cardiovascular Metabolic regulation Physiological regulation Enzyme modulation Ion channel modulation Receptor modulation ACE inhibitory

Half-LifeMammalian: 1.9 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0310167 VERIFIED: YES