Peptide Database

Peptide NameP3378 clusterin-binding peptide

Function Ontology

Anticancer

Anticancer ▸ Tumor Homing Peptide

Delivery / Targeting ▸ Drug delivery vehicle

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC70H97N19O17

DescriptionStandard

        HPLSKHPYWSQP
    

Molecular Weight1476.64 Da

Isoelectric Point (pI)8.61

Net Charge (pH 7.0)0.93

Net Charge (pH 7.4) 0.63

Charge Density (pH 7.0) 0.0777

GRAVY Index-1.55

Hydrophobic Moment 0.18

Boman Index-0.09

Instability Index27.82

Aliphatic Index 32.50

Aromaticity 0.1667

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 560.00

LogP -3.72

H-bond Donors 18.0

H-bond Acceptors 20.0

Rotatable Bonds 39.0

Heavy Atoms 106.0

Ring Count 8.0

Amide Bonds 12.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0020808 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Protein-binding Clusterin-binding Targeting peptide Tumor homing

TargetRecombinant human clusterin

Activity0.30±0.06 μM

MethodPhage-display panning; SPR binding assay (Kd)

RECORD: Rec_0052909 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide; DSSP H 0.0%, E 33.3%, T 16.7%, C 50.0% [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Drug Delivery Vehicle Tumor Homing Peptide