Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length472 amino acids

Chemical FormulaC2299H3607N583O696S27

DescriptionStandard

        MLPSVMVVFAILSCTRAENPAVQVTLTDKWLQYVKHVGAGWIQDKLEHITFPDISGDVDILIGHVYYTLSGIRITKCDLPEPVLEFFQSTGLKTSIVGLNAALVGNWRTSFGIIHDSGSFDMAIFSVSLTSVVQLGRDPDGHLSITSIGCEPQVGNVAIQFHGGASFMFQPFVDHYKDKIVSVIQSNICPNVQTAIDDLESHLQAMSISYDVNEVLTVELPLTSPPVISGDDVNLGLKGEFYSIETHQEPPFVAQPFVLPKEPNYMMSVGLSEFMLNSASFGYFSAGNLQVLVNDSMIPPKSPIHLNTTSMGMFIPQLPKLYPDMLMNLQVYATEAPMLSLQMDVVEVGAQLGAKAFAIEPNGTQVPLFTLSVETRLSGKMWIVDEKLKANAMLDNITLTLASSEVGTFKVKGSLSVAHCVLLVAMQSMFVFADGCFGKRSEDGNKSDGLTQTECTTRRRDCSTTDETSTTG
    

Molecular Weight51415.47 Da

Isoelectric Point (pI)4.81

Net Charge (pH 7.0)-20.56

Net Charge (pH 7.4) -21.54

Charge Density (pH 7.0) -0.0436

GRAVY Index0.15

Hydrophobic Moment 0.58

Boman Index0.17

Instability Index43.67

Aliphatic Index 93.69

Aromaticity 0.0805

Extinction Coeff. Reduced 36900.00

Extinction Coeff. Oxidized 37400.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0241976 VERIFIED: NO

Provenance & Taxonomy

OrganismNothobranchius furzeri [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria