MYP_147884
Compound 3
Antimicrobial
Antiviral
▸
Anti-Flavivirus
▸
Antiviral
▸
Anti-Flavivirus
▸
Antiviral
▸
Antiviral mechanism
▸
Membrane / Ion-channel modulation
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Potassium channel modulation
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Potassium channel inhibitor
not Standard
12 amino acids
-
contains X representing unresolved or non-standard residue
YTNFYLYPYXFC
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Amino Acid Composition
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0008998
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
is attached to thioether-acyl moiety (-S-Ac-) forms a macrocycle through the side chain of the underlined cysteine residue
Amidation
MeYMe= N-methyl-4-O-methyl-tyrosine, Z = MeF= N-methyl-phenylalanine, B = MeS= N-methyl-serine, J = MeG= N-methyl-glycine, U = MeL= N-methyl-leucine, D-Y, D-tyrosine. C-terminal = NH2 at 10; MeYMe= N-methyl-4-O-methyl-tyrosine, Z = MeF= N-methyl-phenylalanine, B = MeS= N-methyl-serine, J = MeG= N-methyl-glycine, U = MeL= N-methyl-leucine, D-Y, D-tyrosine. C-terminal = NH2; Thioether linkage
Bio-Activity Profile
Dengue virus serotype 2 NS2B-NS3 protease
20 μM
IC50
RECORD: Rec_0031687
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
is attached to thioether-acyl moiety (-S-Ac-) forms a macrocycle through the side chain of the underlined cysteine residue
Amidation
MeYMe= N-methyl-4-O-methyl-tyrosine, Z = MeF= N-methyl-phenylalanine, B = MeS= N-methyl-serine, J = MeG= N-methyl-glycine, U = MeL= N-methyl-leucine, D-Y, D-tyrosine. C-terminal = NH2 at 10; MeYMe= N-methyl-4-O-methyl-tyrosine, Z = MeF= N-methyl-phenylalanine, B = MeS= N-methyl-serine, J = MeG= N-methyl-glycine, U = MeL= N-methyl-leucine, D-Y, D-tyrosine. C-terminal = NH2; Thioether linkage
Bio-Activity Profile
West Nile virus NS2B-NS3 protease
20 μM
IC50
RECORD: Rec_0058670
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Cyclization
Amidation
The 'X' at position 10 indicates MeYMe(N-methyl-4-O-methyl-tyrosine)
Bio-Activity Profile
Antimicrobial
Dengue virus serotype 2:inhibition of flaviviral Protease(Zika virus NS2B-NS3 protease) activity in Huh-7 cells
20 μM
IC50
RECORD: Rec_0085277
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Cyclization
Amidation
The 'X' at position 10 indicates MeYMe(N-methyl-4-O-methyl-tyrosine)
Bio-Activity Profile
Antimicrobial
Virus:Zika Virus(ZIKV):inhibition of flaviviral Protease(Zika virus NS2B-NS3 protease) activity in Huh-7 cells
2.2±0.1 μM
IC50
RECORD: Rec_0089334
VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
is attached to thioether-acyl moiety (-S-Ac-) forms a macrocycle through the side chain of the underlined cysteine residue
Amidation
MeYMe= N-methyl-4-O-methyl-tyrosine, Z = MeF= N-methyl-phenylalanine, B = MeS= N-methyl-serine, J = MeG= N-methyl-glycine, U = MeL= N-methyl-leucine, D-Y, D-tyrosine. C-terminal = NH2 at 10; MeYMe= N-methyl-4-O-methyl-tyrosine, Z = MeF= N-methyl-phenylalanine, B = MeS= N-methyl-serine, J = MeG= N-methyl-glycine, U = MeL= N-methyl-leucine, D-Y, D-tyrosine. C-terminal = NH2; Thioether linkage
Bio-Activity Profile
Zika virus NS2B-NS3 protease
2.2±0.1 μM
IC50
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