Peptide Database

Peptide NameBeta-defensin 3

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length63 amino acids

Chemical FormulaC318H515N85O81S8

DescriptionStandard

        MRIHYLLFSFLLVLLSPLSAFSKKVYNAVSCMTNGGICWLKCSGTFREIGSCGTRQLKCCKKK
    

Molecular Weight7081.53 Da

Isoelectric Point (pI)9.70

Net Charge (pH 7.0)8.52

Net Charge (pH 7.4) 8.15

Charge Density (pH 7.0) 0.1353

GRAVY Index0.33

Hydrophobic Moment 0.67

Boman Index0.11

Instability Index41.31

Aliphatic Index 91.27

Aromaticity 0.1111

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8855.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2680.37

LogP -23.02

H-bond Donors 103.0

H-bond Acceptors 99.0

Rotatable Bonds 239.0

Heavy Atoms 492.0

Ring Count 10.0

Amide Bonds 65.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0177384 VERIFIED: NO

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyDefensin

Tax ID10116

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Defensin Non-hemolytic Non-ribosomal

MethodQualitative functional evidence

PaperCross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract PMID16033865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16033865/; https://www.uniprot.org/uniprotkb/Q32ZI4/entry; https://bblserver.org.in/ampdb/