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MYP_147655
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Basic Information
Trichoplaxin
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
22 amino acids
C120H184N36O26
Standard
Sequence
FFGRLKSVWSAVKHGWKAAKSR
Physicochemical Analysis
2546.97 Da
12.00
5.84
5.58
0.2656
-0.44
0.58
-0.09
14.03
57.73
0.1818
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1023.25
-7.82
39.0
33.0
84.0
182.0
7.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0251228 VERIFIED: YES
Provenance & Taxonomy
Trichoplax adhaerens [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer
Human breast adenocarcinoma MCF-7 cells
45–50 μM
IC50
PaperTrichoplaxin - a new membrane-active antimicrobial peptide from placozoan cDNA PMID24530880
RECORD: Rec_0342100 VERIFIED: YES
Provenance & Taxonomy
Trichoplax adhaerens [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida albicans ATCC 90028
25 μM
MIC
PMID24530880 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24530880/
RECORD: Rec_0350540 VERIFIED: YES
Provenance & Taxonomy
Trichoplax adhaerens [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Pseudomonas aeruginosa ATCC 27853
6 μM
MIC
PMID24530880 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24530880/
RECORD: Rec_0356012 VERIFIED: YES
Provenance & Taxonomy
Trichoplax adhaerens [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Escherichia coli ATCC 25922
3–6 μM
MIC
PMID24530880 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24530880/
RECORD: Rec_0356580 VERIFIED: YES
Provenance & Taxonomy
Trichoplax adhaerens [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Rat erythrocytes
20 %
Hemolysis at 800 μM
PaperPubMed PMID: 24530880 PMID24530880 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24530880/
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