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MYP_147655
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Basic Information
Trichoplaxin
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
22 amino acids
C120H184N36O26
Standard
Sequence
FFGRLKSVWSAVKHGWKAAKSR
Physicochemical Analysis
2546.97 Da
12.00
5.84
5.58
0.2656
-0.44
0.58
-0.09
14.03
57.73
0.1818
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1023.25
-7.82
39.0
33.0
84.0
182.0
7.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0150590 VERIFIED: YES
Provenance & Taxonomy
Trichoplax adhaerens [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Rat erythrocytes (20% Hemolysis at 800 microM
800 μM
Hemolysis
PMID24530880 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24530880/
RECORD: Rec_0158282 VERIFIED: YES
Provenance & Taxonomy
Trichoplax adhaerens [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Klebsiella pneumoniae ATCC 13883
6 μM
MIC
PMID24530880 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24530880/
RECORD: Rec_0176716 VERIFIED: YES
Provenance & Taxonomy
Trichoplax adhaerens [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Candida albicans ATCC 90028 and C. parapsilosis ATCC 22019
25-50 μM
MIC
PaperTrichoplaxin - a new membrane-active antimicrobial peptide from placozoan cDNA.
RECORD: Rec_0183249 VERIFIED: YES
Provenance & Taxonomy
Trichoplax adhaerens [Animal]
Trichoplaxin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
PaperBiochim Biophys Acta. 2014 May;1838(5):1430-8. | http://www.ncbi.nlm.nih.gov/pubmed/24530880 PMID24530880 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24530880/
RECORD: Rec_0225710 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
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