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MYP_147655
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Basic Information
Trichoplaxin
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
22 amino acids
C120H184N36O26
Standard
Sequence
FFGRLKSVWSAVKHGWKAAKSR
Physicochemical Analysis
2546.97 Da
12.00
5.84
5.58
0.2656
-0.44
0.58
-0.09
14.03
57.73
0.1818
11000.00
11000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1023.25
-7.82
39.0
33.0
84.0
182.0
7.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0097965 VERIFIED: YES
Provenance & Taxonomy
Trichoplax adhaerens [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Acinetobacter baumannii ATCC 19606
3 μM
MIC
PMID24530880 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24530880/
RECORD: Rec_0128888 VERIFIED: YES
Provenance & Taxonomy
Trichoplax adhaerens [Animal]
10228
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Candida albicans
25 μM
MIC
RECORD: Rec_0130993 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0142078 VERIFIED: YES
Provenance & Taxonomy
Trichoplax adhaerens [Animal]
10228
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
3 μM
MIC
RECORD: Rec_0147810 VERIFIED: YES
Provenance & Taxonomy
Trichoplax adhaerens [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Acinetobacter baumannii ATCC 19606, Klebsiella pneumoniae ATCC 13883
3-6 μM
MIC
PaperTrichoplaxin - a new membrane-active antimicrobial peptide from placozoan cDNA.
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