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MYP_147528
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Basic Information
Pyrrhocoricin
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
20 amino acids
C105H166N32O29
Standard
Sequence
VDKGSYLPRPTPPRPIYNRN
Physicochemical Analysis
2340.64 Da
10.27
2.73
2.52
0.1366
-1.40
0.40
-0.33
30.64
53.50
0.1000
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
988.39
-10.07
33.0
32.0
67.0
166.0
7.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0357596 VERIFIED: YES
Provenance & Taxonomy
Pyrrhocoris apterus [other]
Drosocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Anti-Gram-negative Non-hemolytic
Micrococcus luteus
Antibacterial growth-inhibition assay; exact endpoint unresolved
PMID8002963;10076062 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8002963/
RECORD: Rec_0362358 VERIFIED: YES
Provenance & Taxonomy
Pyrrhocoris apterus [Animal]
Pyrrhocoricin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
1.87 OD_ID
MeX pooled growth assay (4.5 h; NGS-based growth readout)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0370013 VERIFIED: YES
Provenance & Taxonomy
Pyrrhocoris apterus [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Agrobacterium tumefaciens
1.25; 3 μM
MIC (LB; PB, respectively)
PMID10076062;8002963;23562829 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10076062/
RECORD: Rec_0373177 VERIFIED: NO
Provenance & Taxonomy
Pyrrhocoris apterus [Animal]
drosocin family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial drosocin family Antibacterial Host defense
PaperPDB 3DPQ structural record; X-ray; 2.60 A; chain C/D/G/H; residues 7-20
RECORD: Rec_0398063 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer
PaperMethods of treating cancer by inhibiting bacterial DnaK (patent provenance) PatentWO 2023/196891 A2
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