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MYP_147528
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Basic Information
Pyrrhocoricin
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
20 amino acids
C105H166N32O29
Standard
Sequence
VDKGSYLPRPTPPRPIYNRN
Physicochemical Analysis
2340.64 Da
10.27
2.73
2.52
0.1366
-1.40
0.40
-0.33
30.64
53.50
0.1000
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
988.39
-10.07
33.0
32.0
67.0
166.0
7.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0006115 VERIFIED: YES
Provenance & Taxonomy
Pyrrhocoris apterus [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
L.B, P.B)
80 μM
MIC
PMID10076062;8002963;23562829 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10076062/
RECORD: Rec_0026045 VERIFIED: YES
Provenance & Taxonomy
Pyrrhocoris apterus [other]
Drosocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative Non-hemolytic
Enterobacter cloacae
PMID8002963;10076062 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8002963/
RECORD: Rec_0033373 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperHoffmann R., Bulet P., Urge L., Otvoes L. Jr.;. "Range of activity and metabolic stability of synthetic antibacterial glycopeptides from insects."; Biochim. Biophys. Acta 1426:459-467. Evidence URLhttps://www.uniprot.org/uniprotkb/PYRR_PYRAP/entry
RECORD: Rec_0041982 VERIFIED: YES
Provenance & Taxonomy
European fire bug [Animal]
Pyrrhocoricin
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Bio-Activity Profile
Antimicrobial
Micrococcus luteus
5-10 μM
MIC
PaperNovel inducible antibacterial peptides from a hemipteran insect, the sap-sucking bug Pyrrhocoris apterus.
RECORD: Rec_0105555 VERIFIED: YES
Provenance & Taxonomy
European fire bug [Animal]
Pyrrhocoricin
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Bio-Activity Profile
Antimicrobial
lower, E cloacae beta12
5-10 μM
MIC
PaperNovel inducible antibacterial peptides from a hemipteran insect, the sap-sucking bug Pyrrhocoris apterus.
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