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MYP_147527
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Basic Information
Esculentin-2LTa
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
37 amino acids
C177H280N50O45S2
Standard
Sequence
GIFSLFKAGAKFFGKHLLKQAGKAGAEHLACKATNQC
Physicochemical Analysis
3892.55 Da
9.79
4.91
4.57
0.1327
0.03
0.61
0.12
-0.01
71.62
0.1081
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1531.43
-14.44
54.0
54.0
134.0
274.0
6.0
39.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0184963 VERIFIED: YES
Provenance & Taxonomy
Hylarana latouchii [Animal]
Esculentin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
31-37
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Psychrobacter faecalis X29
1.6 μM
MIC
PMID22426384 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22426384/
RECORD: Rec_0190710 VERIFIED: YES
Provenance & Taxonomy
Hylarana latouchii [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0194885 VERIFIED: YES
Provenance & Taxonomy
Hylarana latouchii [Animal]
Esculentin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
31-37
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Rhodococcus rhodochrous X15
0.8 μM
MIC
PMID22426384 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22426384/
RECORD: Rec_0223857 VERIFIED: YES
Provenance & Taxonomy
Hylarana latouchii [Animal]
Esculentin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
31-37
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus ATCC2592
1.6 μM
MIC
PMID22426384 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22426384/
RECORD: Rec_0241971 VERIFIED: YES
Provenance & Taxonomy
Hylarana latouchii [Animal]
Esculentin
156873
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
31-37
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus ATCC 2592
1.6 μM
MIC
PaperMolecular cloning and characterization of antimicrobial peptides from skin of the broad-folded frog, Hylarana latouchii.
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