Peptide Database

Peptide NameOvine corticotropic releasing factor

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Stress-related neuropeptide

Regulatory peptide ▸ Biological modulation

Standard StatusStandard

Sequence Length41 amino acids

Chemical FormulaC205H338N58O64S

DescriptionStandard

        SQEPPISLDLTFHLLREVLEMTKADQLAQQAHSNRKLLDIA
    

Molecular Weight4671.29 Da

Isoelectric Point (pI)5.40

Net Charge (pH 7.0)-2.36

Net Charge (pH 7.4) -2.67

Charge Density (pH 7.0) -0.0575

GRAVY Index-0.32

Hydrophobic Moment 0.65

Boman Index-0.04

Instability Index34.04

Aliphatic Index 111.95

Aromaticity 0.0244

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1983.34

LogP -18.59

H-bond Donors 66.0

H-bond Acceptors 65.0

Rotatable Bonds 159.0

Heavy Atoms 328.0

Ring Count 5.0

Amide Bonds 45.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0426851 VERIFIED: YES

Provenance & Taxonomy

OrganismOvis aries [Animal]

FamilyCorticoliberin

Tax ID9940

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Receptor modulation

Targetfrom pituitary gland

Half-LifeExperimental: The plasma half-life of IR-CRF was 11.6 +/- 1.5 min (mean +/- SE) for the fast component and 73 +/- 8 min for the slow component.; Mammalian: 1.9 hour; Yeast: >20 hour; E. coli: >10 hour

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