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MYP_147118
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Basic Information
beta-casomorphin-7 immunomodulating
Anticancer
Anticancer ▸ Anti-breast cancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ BChE Inhibitory
Hemostasis ▸ Antithrombotic activity
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid agonist
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid antagonist
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid receptor ligand
Neurological / Signaling ▸ Neuroactive peptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Sensory / Food function ▸ Taste-active peptide
Sensory / Food function ▸ Taste-active peptide ▸ Bitter peptide
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
7 amino acids
C41H55N7O9
Standard
Sequence
YPFPGPI
Physicochemical Analysis
789.92 Da
5.52
-0.24
-0.45
-0.0344
0.11
0.25
0.52
81.23
55.71
0.2857
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
231.78
0.69
6.0
9.0
16.0
57.0
5.0
6.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0379119 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
beta-Casein-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Immunomodulatory
Mice
PaperConsumption of β-casomorphins-7/5 induce inflammatory immune response in mice gut through Th-2 pathway | Ul Haq, MR. et al. | DOI: 10.1016/j.jff.2014.03.018 Evidence URLhttps://www.uniprot.org/uniprotkb/P02666/entry
RECORD: Rec_0397150 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Casein-derived peptide
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide Enzyme inhibitory Immunomodulator Taste
acts as an opiate
14 μM
IC50
RECORD: Rec_0403350 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
beta-Casein-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
ACE inhibitory Antihypertensive
Angiotensin-converting enzyme (ACE)
500 μM
IC50
PaperRelease of angiotensin converting enzyme-inhibitory peptides by simulated gastrointestinal digestion of infant formulas | Hernandez-Ledesma, B. et al. | DOI: 10.1016/j.idairyj.2004.02.011 Evidence URLhttps://www.uniprot.org/uniprotkb/P02666/entry
RECORD: Rec_0414786 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Casomorphin
9913
Structure & Mods
synthetic linear peptide [Linear]
all-D amino-acid peptide [D]
Bio-Activity Profile
Anticancer Cytotoxic Anti-breast cancer Cell-proliferative
decreased breastcancer cell proliferation
Cell proliferation assay
PaperAntiproliferative and receptor binding properties of α- and β-casomorphins in the T47D human breast cancer cell line | Hatzoglou, A. et al. | DOI: 10.1016/0014-2999(96)00339-1 Evidence URLhttps://www.uniprot.org/uniprotkb/P02666/entry
RECORD: Rec_0425959 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Casomorphin
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Mucin secretagogue Gastroprotective
PaperMilk Bioactive Peptides and -Casomorphins Induce Mucus Release in Rat Jejunum | Trompette, A. et al. | DOI: 10.1093/jn/133.11.3499 Evidence URLhttps://www.uniprot.org/uniprotkb/P02666/entry
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