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MYP_147118
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Basic Information
beta-casomorphin-7 immunomodulating
Anticancer
Anticancer ▸ Anti-breast cancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ BChE Inhibitory
Hemostasis ▸ Antithrombotic activity
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid agonist
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid antagonist
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid receptor ligand
Neurological / Signaling ▸ Neuroactive peptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Sensory / Food function ▸ Taste-active peptide
Sensory / Food function ▸ Taste-active peptide ▸ Bitter peptide
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
7 amino acids
C41H55N7O9
Standard
Sequence
YPFPGPI
Physicochemical Analysis
789.92 Da
5.52
-0.24
-0.45
-0.0344
0.11
0.25
0.52
81.23
55.71
0.2857
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
231.78
0.69
6.0
9.0
16.0
57.0
5.0
6.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0334251 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Casomorphin
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Opioid receptor ligand Mucin secretagogue
HT29-MTX cells
Mucin secretion assay
PaperFood-Derived Peptides Stimulate Mucin Secretion and Gene Expression in Intestinal Cells | Martinez-Maqueda, D. et al. | DOI: 10.1021/jf301279k Evidence URLhttps://www.uniprot.org/uniprotkb/P02666/entry
RECORD: Rec_0334860 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
beta-Casein-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Phosphorylation
Bio-Activity Profile
Opioid receptor ligand
PaperBiologically active peptides in milk proteins | Meisel, H. et al. | DOI: 10.1007/BF02019390 Evidence URLhttps://www.uniprot.org/uniprotkb/P02666/entry
RECORD: Rec_0342572 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Casomorphin
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Mucin secretagogue Gastroprotective Opioid antagonist
HT29-MTX cells
Mucin secretion assay
Paperβ-Casomorphin-7 regulates the secretion and expression of gastrointestinal mucins through a u-opioid pathway | Zoghbi, S. et al. | DOI: 10.1152/ajpgi.00455.2005 Evidence URLhttps://www.uniprot.org/uniprotkb/P02666/entry
RECORD: Rec_0342913 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Casomorphin
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antioxidant Nitric oxide-modulating Superoxide scavenging
Rats
Superoxide scavenging assay
Paperβ-Casomorphin-7 Cause Decreasing in Oxidative Stress and Inhibiting NF-kappaB-iNOS-NO Signal Pathway in Pancreas of Diabetes Rats | Yin, H. et al. | DOI: 10.1111/j.1750-3841.2011.02577.x Evidence URLhttps://www.uniprot.org/uniprotkb/P02666/entry
RECORD: Rec_0348370 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
ACE-inhibitory peptide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
ACE
500 μM
IC50
PaperACE inhibitory peptides
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