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MYP_147118
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Basic Information
beta-casomorphin-7 immunomodulating
Anticancer
Anticancer ▸ Anti-breast cancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ BChE Inhibitory
Hemostasis ▸ Antithrombotic activity
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid agonist
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid antagonist
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid receptor ligand
Neurological / Signaling ▸ Neuroactive peptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Sensory / Food function ▸ Taste-active peptide
Sensory / Food function ▸ Taste-active peptide ▸ Bitter peptide
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
7 amino acids
C41H55N7O9
Standard
Sequence
YPFPGPI
Physicochemical Analysis
789.92 Da
5.52
-0.24
-0.45
-0.0344
0.11
0.25
0.52
81.23
55.71
0.2857
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
231.78
0.69
6.0
9.0
16.0
57.0
5.0
6.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0198741 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Casomorphin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuroactive BChE Inhibitory
194.7
PaperJi D., Ma J., Dai J., Xu M., Harris, P. W. R., Brimble M. A., Agyei D.. Anticholinesterase inhibition, drug-likeness assessment, and molecular docking evaluation of milk protein-derived opioid peptides for the control of Alzheimer¡¯s disease. Dairy, 3, 422-437, 2022.
RECORD: Rec_0212809 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antihypertensive
PaperAHTPDB: a comprehensive platform for analysis and presentation of antihypertensive peptides PMID25392419 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25392419/
RECORD: Rec_0213361 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Casomorphin
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Opioid receptor ligand Opioid agonist
PaperContents of agonistic and antagonistic opioid peptides in different cheese varieties | Sienkiewicz-Szłapka, E. et al. | DOI: 10.1016/j.idairyj.2008.10.011 Evidence URLhttps://www.uniprot.org/uniprotkb/P02666/entry
RECORD: Rec_0224546 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Casomorphin
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Mucin secretagogue Gastroprotective Opioid antagonist
Mucin secretion assay
PaperEffects of peptides derived from dietary proteins on mucus secretion in rat jejunum | Claustre, J. et al. | DOI: 10.1152/ajpgi.00535.2001 Evidence URLhttps://www.uniprot.org/uniprotkb/P02666/entry
RECORD: Rec_0231373 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
Angiotensin-converting enzyme (ACE)
500.0
IC50
PaperMeisel H., Walsh D. J., Murray B., FitzGerald R. J.. ACE inhibitory peptides. in: Nutraceutical proteins and peptides in health and disease. Mine Y., Shahidi F. (Eds.), CRC Taylor & Francis Group, Boca Raton, London, New York, 269-315, 2006.
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