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MYP_147118
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Basic Information
beta-casomorphin-7 immunomodulating
Anticancer
Anticancer ▸ Anti-breast cancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Enzyme modulation ▸ Enzyme inhibition ▸ BChE Inhibitory
Hemostasis ▸ Antithrombotic activity
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid agonist
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid antagonist
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid receptor ligand
Neurological / Signaling ▸ Neuroactive peptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Sensory / Food function ▸ Taste-active peptide
Sensory / Food function ▸ Taste-active peptide ▸ Bitter peptide
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
7 amino acids
C41H55N7O9
Standard
Sequence
YPFPGPI
Physicochemical Analysis
789.92 Da
5.52
-0.24
-0.45
-0.0344
0.11
0.25
0.52
81.23
55.71
0.2857
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
231.78
0.69
6.0
9.0
16.0
57.0
5.0
6.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0050974 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Casomorphin
9913;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Opioid Agonist
opioid receptor
14.0
PaperHenschen A., Lottspeich F., Brantl V., Teschemacher H.. Novel opioid peptides derivrd from casein (beta-casomorphins). II. Structure of active components from bovine casein peptone. Hoppe-Seyler's Z. Physiol. Chem., 360, 1217-1224, 1979.
RECORD: Rec_0062089 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Casein-derived peptide
9913
Structure & Mods
linear contiguous peptide sequence [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Bitter
6.3 Rcaf
Relative bitterness (Rcaf)
PaperBitter taste of H-Pro-Phe-Pro-Gly-Pro-Ile-Pro-OH corresponding to the partial sequence (positions 61-67) of bovine beta-casein, and related peptides. Agric. Biol. Chem., 50, 1986, 1247-1254
RECORD: Rec_0063494 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Casomorphin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Acetylcholinesterase inhibitory
4255.0
PaperJi D., Ma J., Dai J., Xu M., Harris, P. W. R., Brimble M. A., Agyei D.. Anticholinesterase inhibition, drug-likeness assessment, and molecular docking evaluation of milk protein-derived opioid peptides for the control of Alzheimer¡¯s disease. Dairy, 3, 422-437, 2022.
RECORD: Rec_0072511 VERIFIED: NO
Provenance & Taxonomy
Bos taurus [Animal]
Opioid peptide
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Opioid
RECORD: Rec_0075918 VERIFIED: NO
Provenance & Taxonomy
Bos taurus [Animal]
99130
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antithrombotic
Thrombin
PaperSequence analysis and molecular docking of antithrombotic peptides from casein hydrolysate by trypsin digestion. Journal of Functional Foods 32:313-323 (2017). DOI: 10.1016/j.jff.2017.03.015.
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