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MYP_146955
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Basic Information
Desotamide E
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
6 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
WLVXNG
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0282476 VERIFIED: NO
Provenance & Taxonomy
Streptomyces nov. [Bacterium]
Structure & Mods
cyclic hexapeptide [Cyclic]
mixed L/D or noncanonical cyclic peptide [Mixed]
None
None
X=Allo-Ile; v=D-Val
Bio-Activity Profile
Antimicrobial Anticancer
>30 μM
Cytotoxicity assay; inactive up to tested concentration
PMID25229313 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25229313/
RECORD: Rec_0331752 VERIFIED: YES
Provenance & Taxonomy
Streptomyces nov. sp. [Bacterium]
Structure & Mods
cyclic hexapeptide [Cyclic]
mixed L/D or noncanonical cyclic peptide [Mixed]
unspecified non-canonical residue at 4
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Pseudomonas aeruginosa ATCC 10145
30 μM
IC50
PMID25229313 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25229313/
RECORD: Rec_0350539 VERIFIED: YES
Provenance & Taxonomy
Streptomyces nov. sp. [Bacterium]
Structure & Mods
cyclic hexapeptide [Cyclic]
mixed L/D or noncanonical cyclic peptide [Mixed]
unspecified non-canonical residue at 4
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Bacillus subtilis ATCC 6051
5.2 μM
IC50
PMID25229313 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25229313/
RECORD: Rec_0383885 VERIFIED: YES
Provenance & Taxonomy
Streptomyces nov. sp. [Bacterium]
Structure & Mods
cyclic hexapeptide [Cyclic]
mixed L/D or noncanonical cyclic peptide [Mixed]
unspecified non-canonical residue at 4
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Mycobacterium bovis BCG
Qualitative functional evidence
PMID25229313 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25229313/
RECORD: Rec_0414966 VERIFIED: YES
Provenance & Taxonomy
Streptomyces nov. sp. [Bacterium]
Structure & Mods
cyclic hexapeptide [Cyclic]
mixed L/D or noncanonical cyclic peptide [Mixed]
unspecified non-canonical residue at 4
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Staphylococcus aureus ATCC 9144
30 μM
IC50
PMID25229313 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25229313/
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