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MYP_146955
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Basic Information
Desotamide E
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
6 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
WLVXNG
Physicochemical Analysis
0.00 Da
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0.00
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0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0041790 VERIFIED: YES
Provenance & Taxonomy
Streptomyces nov. [Bacterium]
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
mixed L/D or modified amino-acid peptide [Mixed]
None
None
X=Allo-Ile; v=D-Val
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PMID25229313 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25229313/
RECORD: Rec_0082263 VERIFIED: YES
Provenance & Taxonomy
Streptomyces nov. sp. [Bacterium]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
unspecified non-canonical residue at 4
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Escherichia coli ATCC 11775
30 μM
IC50
PMID25229313 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25229313/
RECORD: Rec_0084259 VERIFIED: YES
Provenance & Taxonomy
Streptomyces nov. sp. [Bacterium]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
unspecified non-canonical residue at 4
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Bacillus subtilis ATCC 6633
15 μM
MIC
PMID25229313 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25229313/
RECORD: Rec_0107408 VERIFIED: YES
Provenance & Taxonomy
Streptomyces nov. [Bacterium]
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
mixed L/D or modified amino-acid peptide [Mixed]
None
None
X=Allo-Ile; v=D-Val
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: NCI-H460 (Not active up to 30 μM)
PMID25229313 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25229313/
RECORD: Rec_0131423 VERIFIED: YES
Provenance & Taxonomy
Streptomyces nov. sp. [Bacterium]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
unspecified non-canonical residue at 4
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Staphylococcus aureus ATCC 25923
30 μM
IC50
PMID25229313 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25229313/
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