Peptide Database

Peptide NameSLAY-screened peptide P4917

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC117H170N28O27S3

DescriptionStandard

        CPGRLHTCFDLWYPMVLIAFN
    

Molecular Weight2496.97 Da

Isoelectric Point (pI)6.73

Net Charge (pH 7.0)-0.17

Net Charge (pH 7.4) -0.46

Charge Density (pH 7.0) -0.0082

GRAVY Index0.63

Hydrophobic Moment 0.34

Boman Index0.33

Instability Index34.54

Aliphatic Index 92.86

Aromaticity 0.1905

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7115.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 854.96

LogP -2.67

H-bond Donors 31.0

H-bond Acceptors 31.0

Rotatable Bonds 72.0

Heavy Atoms 175.0

Ring Count 8.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0417386 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/