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MYP_146873
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Basic Information
Cecropin magainin hybrid, synthetic peptide
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
17 amino acids
C110H173N27O19
Standard
Sequence
KWKLFKKIKFLHSAKKF
Physicochemical Analysis
2177.72 Da
10.78
6.84
6.58
0.4024
-0.58
0.47
-0.15
-14.41
74.71
0.2353
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
775.76
-0.37
28.0
27.0
78.0
156.0
6.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0299341 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Candida glabrata
512 μg/mL
MIC
PMID33676184 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33676184/
RECORD: Rec_0353591 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial
Human erythrocytes
100 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/10675500/ PMID10675500 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10675500/
RECORD: Rec_0366939 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Antiviral Antiparasitic Antiplasmodial
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
RECORD: Rec_0407344 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cecropin A-Magainin 2 hinge-modified peptides
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Antimicrobial
Jurkat (blood cancer)
65 μM
IC50
PaperEffects of the hinge region of cecropin A(1-8)-magainin 2(1-12), a synthetic antimicrobial peptide, on liposomes, bacterial and tumor cells | https://pubmed.ncbi.nlm.nih.gov/10675500/ PMID10675500 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10675500/
RECORD: Rec_0420883 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cecropin A-Magainin 2 hinge-modified peptides
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Antimicrobial
A-549 (lung cancer)
100 μM
IC50
PaperEffects of the hinge region of cecropin A(1-8)-magainin 2(1-12), a synthetic antimicrobial peptide, on liposomes, bacterial and tumor cells | https://pubmed.ncbi.nlm.nih.gov/10675500/ PMID10675500 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10675500/
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