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MYP_146873
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Basic Information
Cecropin magainin hybrid, synthetic peptide
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal ▸ Antimalarial ▸ Anti-Plasmodium
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
17 amino acids
C110H173N27O19
Standard
Sequence
KWKLFKKIKFLHSAKKF
Physicochemical Analysis
2177.72 Da
10.78
6.84
6.58
0.4024
-0.58
0.47
-0.15
-14.41
74.71
0.2353
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
775.76
-0.37
28.0
27.0
78.0
156.0
6.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0081533 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Cecropin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0112631 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
Cecropin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
No hemolytic activity against human erythrocytes
Hemolysis
Evidence URLhttps://www.uniprot.org/uniprotkb/P01507/entry
RECORD: Rec_0200715 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cecropin
32630
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperPubMed PMID: 11009597 PMID11009597 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11009597/
RECORD: Rec_0219442 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cecropin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Cytotoxic
A-549
100 μM
IC50
PMID10675500 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10675500/
RECORD: Rec_0224178 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cecropin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Cytotoxic
Jurkat
65 μM
IC50
PMID10675500 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10675500/
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