Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length448 amino acids

Chemical FormulaC2174H3458N540O659S16

DescriptionStandard

        MLSLCCVLALLVLSCPEICGTNAGVKVKLTQKGLEYGRQIGVTTLLDQFKTIKVPDFSGSEEVSPIGKVSYSLTGIKVINVGLPQSEVALVPGTGVSLTISNAYINLHGDWRVKYLGIISDSSCFDLVVSELSISTTVTIQSDDTGRPVVSSANCAASVGQTSVTFHGGASWLYNLFSSYIDDALRSVLQRKICPLVSDAIHNLNPYLKALNVLAKVDQYAEIEYSMVESPVISTSSIDLSLKGEFYNIGEHKEPPFAPTPFSLPPDESNMLYMGISAFTANSAGFVYNNAGALSLIITDDMIPSSSPFRLNTKTFGTFIPQIAKQYPDLMMELLVKAATAPTVTFTPNNLTLQANATITAYAIQPNTTLTTLFNLNVVSNKGQTVVEVKSLDSIFQMVLKAAVIAEVNDLLQQGFPLPAIGELNLVNTQLVIMKDYLLIGTDIHFTA
    

Molecular Weight48216.97 Da

Isoelectric Point (pI)4.94

Net Charge (pH 7.0)-11.10

Net Charge (pH 7.4) -11.76

Charge Density (pH 7.0) -0.0248

GRAVY Index0.29

Hydrophobic Moment 0.70

Boman Index0.21

Instability Index35.86

Aliphatic Index 107.03

Aromaticity 0.0781

Extinction Coeff. Reduced 33350.00

Extinction Coeff. Oxidized 33725.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0376542 VERIFIED: NO

Provenance & Taxonomy

OrganismElectrophorus electricus [Animal]

FamilyBPI

Tax ID8005

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence