Peptide Database

Peptide NameVpr 57-71

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition

Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition

Enzyme modulation ▸ Enzyme inhibition ▸ Reverse transcriptase inhibition

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC86H144N22O20

DescriptionStandard

        VEAIIRILQQLLFIH
    

Molecular Weight1806.20 Da

Isoelectric Point (pI)6.72

Net Charge (pH 7.0)-0.18

Net Charge (pH 7.4) -0.44

Charge Density (pH 7.0) -0.0117

GRAVY Index1.33

Hydrophobic Moment 0.76

Boman Index0.41

Instability Index64.97

Aliphatic Index 208.00

Aromaticity 0.0667

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 684.78

LogP -0.95

H-bond Donors 23.0

H-bond Acceptors 21.0

Rotatable Bonds 61.0

Heavy Atoms 128.0

Ring Count 2.0

Amide Bonds 16.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0325111 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Replication inhibition

TargetHIV-1

Activity0.22 μM

MethodIC50

Half-LifeMammalian: 100 h; Yeast: >20 h; E. coli: >10 h

PaperInhibition of the activities of reverse transcriptase and integrase of human immunodeficiency virus type-1 by peptides derived from the homologous viral protein R (Vpr). | Gleenberg IO, Herschhorn A, Hizi A. | J Mol Biol. 2007 Jun 22;369(5):1230-43. | DOI:10.1016/j.jmb.2007.03.073 | PMID:17490682 PMID17490682 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17490682/

RECORD: Rec_0426990 VERIFIED: NO