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MYP_146783
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Basic Information
Vpr 57-71
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Reverse transcriptase inhibition
Standard
15 amino acids
C86H144N22O20
Standard
Sequence
VEAIIRILQQLLFIH
Physicochemical Analysis
1806.20 Da
6.72
-0.18
-0.44
-0.0117
1.33
0.76
0.41
64.97
208.00
0.0667
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
684.78
-0.95
23.0
21.0
61.0
128.0
2.0
16.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0010072 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
inhibit the activity of DNA-dependent DNA polymerase
0.22 μM
IC50
PMID17490682 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17490682/
RECORD: Rec_0021067 VERIFIED: YES
Provenance & Taxonomy
Human immunodeficiency virus 1 [Virus]
11676
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Reverse transcriptase inhibition
0.22 μM
IC50
PaperInhibition of the activities of reverse transcriptase and integrase of human immunodeficiency virus type-1 by peptides derived from the homologous viral protein R (Vpr). PMID17490682 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17490682/
RECORD: Rec_0038143 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Replication inhibition
inhibit the activity of Rnase H
2 μM
IC50
Mammalian: 100 h; Yeast: >20 h; E. coli: >10 h
PaperInhibition of the activities of reverse transcriptase and integrase of human immunodeficiency virus type-1 by peptides derived from the homologous viral protein R (Vpr). | Gleenberg IO, Herschhorn A, Hizi A. | J Mol Biol. 2007 Jun 22;369(5):1230-43. | DOI:10.1016/j.jmb.2007.03.073 | PMID:17490682 PMID17490682 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17490682/
RECORD: Rec_0144271 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperHIPdb: a database of experimentally validated HIV inhibiting peptides PMID23359817 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23359817/
RECORD: Rec_0155535 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Inhibition of 3′-end processing catalyzed by integrase
7.8 μM
IC50
PMID17490682 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17490682/
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