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MYP_146736
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Basic Information
[K7, P8, K11]-IsCT (IsCT analog through amino acids substitution)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
12 amino acids
C76H127N17O13
Standard
Sequence
ILGKIWKIKKLF
Physicochemical Analysis
1486.93 Da
10.48
3.76
3.55
0.3130
0.58
0.39
0.23
-10.16
162.50
0.1667
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
503.29
2.08
18.0
17.0
53.0
106.0
3.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0011425 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus KCTC 1621
2 μM
MIC
PaperPubMed PMID: 15369808 PMID15369808 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15369808/
RECORD: Rec_0059342 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Human erythrocytes
100 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/15369808/ PMID15369808 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15369808/
RECORD: Rec_0082667 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Toxic Hemolytic
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
RECORD: Rec_0138344 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
multidrug-resistant Pseudomonas aeruginosa (MDRPA) (CCARM 3543) (MIC=1 μM) and multidrug-resistant Pseudomonas aeruginosa (MDRPA) CCARM 2095
1 μM
MIC
PaperPubMed PMID: 15369808 PMID15369808 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15369808/
RECORD: Rec_0186102 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 33.3%, C 66.7% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial
PaperCAMP: Collection of sequences and structures of antimicrobial peptides PMID24265220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24265220/
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