Peptide Database

Peptide NameCircularin A uberolysin family circular bacteriocin

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length95 amino acids

Chemical FormulaC448H733N111O116S3

DescriptionStandard

        MKLNNVLFNKKMYMGVAFVLVAFAISLTQPHLTSTLGISAYAAKKVIDIISAASSVAAVVGIIAAVVGGGGIGVAVLATAKALVKKYGKAYAAAW
    

Molecular Weight9626.48 Da

Isoelectric Point (pI)10.07

Net Charge (pH 7.0)7.58

Net Charge (pH 7.4) 7.29

Charge Density (pH 7.0) 0.0797

GRAVY Index1.01

Hydrophobic Moment 0.57

Boman Index0.40

Instability Index26.73

Aliphatic Index 126.42

Aromaticity 0.0842

Extinction Coeff. Reduced 11460.00

Extinction Coeff. Oxidized 11460.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3561.46

LogP -26.70

H-bond Donors 125.0

H-bond Acceptors 128.0

Rotatable Bonds 317.0

Heavy Atoms 678.0

Ring Count 11.0

Amide Bonds 98.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0122822 VERIFIED: NO

Provenance & Taxonomy

OrganismEnterococcus faecalis EnGen0359 [Bacterium]

FamilyBacteriocin

Tax ID1169307

Structure & Mods

Confighead-to-tail cyclic peptide [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

Other ModsCyclized peptide scaffold annotation

Bio-Activity Profile

Function

Antibiotic Antimicrobial Bacteriocin Non-hemolytic Non-ribosomal