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MYP_146601
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Basic Information
E2EM15W
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
15 amino acids
C82H135N21O18
Standard
Sequence
TLKQFAKGVGKWLVK
Physicochemical Analysis
1703.08 Da
10.48
3.39
3.20
0.2263
-0.06
0.72
0.06
3.73
97.33
0.1333
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
653.91
-3.00
23.0
22.0
59.0
121.0
3.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0110594 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Klebsiella pneumonia
200 μg/mL
MIC
PMID24211019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24211019/
RECORD: Rec_0159502 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Esculentin
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
The Ⓧ (position: 6 and 10) in sequence indicates (S)-α-methyl, α-pentenylglycine. Ⓧ (6) and Ⓧ (10) are cross-linked by hydrocarbon stapling through an oct-4-enyl staple
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus epidermidis
>200 μg/mL
MIC
PaperThanh Kim Pham, Do-Hee Kim, Bong-Jin Lee, Young-Woo Kim. Truncated and constrained helical analogs of antimicrobial esculentin-2EM. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6717-20. Epub 2013 Oct 26. PMID24211019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24211019/
RECORD: Rec_0164930 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
200 μg/mL
MIC
PMID24211019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24211019/
RECORD: Rec_0177922 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Proteus mirabilis
200 μg/mL
MIC
PMID24211019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24211019/
RECORD: Rec_0181569 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic
PMID24211019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24211019/
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