Peptide Database

Peptide NameSLAY-screened peptide P980

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC120H162N32O32

DescriptionStandard

        YAYSPHVYAHTFQRDYYRNL
    

Molecular Weight2564.77 Da

Isoelectric Point (pI)8.39

Net Charge (pH 7.0)0.93

Net Charge (pH 7.4) 0.62

Charge Density (pH 7.0) 0.0465

GRAVY Index-1.05

Hydrophobic Moment 0.59

Boman Index-0.13

Instability Index53.42

Aliphatic Index 44.00

Aromaticity 0.3000

Extinction Coeff. Reduced 7450.00

Extinction Coeff. Oxidized 7450.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1053.68

LogP -7.71

H-bond Donors 38.0

H-bond Acceptors 35.0

Rotatable Bonds 74.0

Heavy Atoms 184.0

Ring Count 9.0

Amide Bonds 21.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0126856 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/