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MYP_146458
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Basic Information
Vitri F
Anticancer
Anticancer ▸ Antitumor
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
31 amino acids
C138H223N35O42S6
Standard
Sequence
GTLPCGESCVWIPCISSVVGCACKSKVCYKD
Physicochemical Analysis
3236.85 Da
7.77
0.70
0.40
0.0227
0.55
0.41
0.20
34.13
78.39
0.0645
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1208.57
-13.04
48.0
49.0
101.0
221.0
5.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0014708 VERIFIED: YES
Provenance & Taxonomy
Viola tricolor [Plant]
Cyclotide
214053
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Anticancer Cytotoxic Enzymatic-degradation Antimicrobial
Human breast adenocarcinoma MDA-MB-231
2.74 μg/mL
IC50
PaperPeptidomics of Circular Cysteine-Rich Plant Peptides: Analysis of the Diversity of Cyclotides from Viola tricolor by Transcriptome and Proteome Mining | PubMed PMID 20580650 PMID20580650;26399495 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580650/
RECORD: Rec_0018753 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer
RECORD: Rec_0079239 VERIFIED: YES
Provenance & Taxonomy
Viola tricolor [Plant]
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PaperPubMed PMID: 20580652 PMID20580652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580652/
RECORD: Rec_0126734 VERIFIED: YES
Provenance & Taxonomy
Viola tricolor [Plant]
Cyclotide
214053
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Anticancer Cytotoxic Enzymatic-degradation Antimicrobial
Human lung carcinoma A549
3.58 μg/mL
IC50
PaperPeptidomics of Circular Cysteine-Rich Plant Peptides: Analysis of the Diversity of Cyclotides from Viola tricolor by Transcriptome and Proteome Mining | PubMed PMID 20580650 PMID20580650;26399495 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580650/
RECORD: Rec_0166082 VERIFIED: YES
Provenance & Taxonomy
Viola tricolor [Plant]
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
BEL-7402
5.36 μg/mL
IC50
PaperPubMed PMID: 20580652 PMID20580652 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580652/
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