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MYP_146404
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Basic Information
HBD4
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
37 amino acids
C180H301N63O52S6
Standard
Sequence
ELDRICGYGTARCRKKCRSQEYRIGRCPNTYACCLRK
Physicochemical Analysis
4372.10 Da
9.50
6.78
6.51
0.1831
-0.93
0.58
-0.44
50.12
47.57
0.0811
4470.00
4845.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1932.95
-22.77
78.0
65.0
148.0
301.0
4.0
38.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0000640 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
6-33, 13-27, 17-34
C33, C13:C27, C17:C34
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
LC
12 μM
PMID23000475 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23000475/
RECORD: Rec_0003795 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
6-33, 13-27, 17-34
C33, C13:C27, C17:C34
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
PMID23000475 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23000475/
RECORD: Rec_0017411 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
6-33, 13-27, 17-34
C33, C13:C27, C17:C34
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
LC
7.5 μM
PMID23000475 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23000475/
RECORD: Rec_0041103 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Staphylococcus carnosus TM300
4.5 μg/mL
MIC
PMID11481241 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11481241/
RECORD: Rec_0106651 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa
4.1 μg/mL
MIC
PMID11481241 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11481241/
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