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MYP_146378
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Basic Information
JEV Ep (424452)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Flavivirus ▸ Anti-Japanese encephalitis virus
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
29 amino acids
C142H208N40O37
Standard
Sequence
AWDFGSIGGVFNSIGRAVHQVFGGAFRTL
Physicochemical Analysis
3067.42 Da
9.65
0.88
0.64
0.0305
0.47
0.76
0.31
10.04
80.69
0.1724
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1230.56
-11.90
44.0
39.0
96.0
219.0
7.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0002991 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Japanese encephalitis virus (JEV)
PMID28232248 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28232248/
RECORD: Rec_0116010 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Japanese encephalitis virus (JEV):inhibition of JEV infection in BHK-21 (baby hamster kidney) cells
0.00766 μM
IC50
PMID28232248 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28232248/
RECORD: Rec_0117272 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Baby Hamster Kidney cells BHK-21
25 % Cell death
Cell death
PMID28232248 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28232248/
RECORD: Rec_0173328 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-JEV Entry inhibition
Japanese encephalitis virus (JEV)
0.00766 μM
IC50
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperAntiviral activity of peptide inhibitors derived from the protein E stem against Japanese encephalitis and Zika viruses. | Chen L, Liu Y, Wang S, Sun J, Wang P, Xin Q, Zhang L, Xiao G, Wang W. | Antiviral Res. 2017 May;141:140-149. | DOI:10.1016/j.antiviral.2017.02.009 | PMID:28232248 PMID28232248 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28232248/