Peptide Database

Peptide NameEsculentin-2PLa

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length78 amino acids

Chemical FormulaC375H632N96O111S8

DescriptionStandard

        MFTTKKSMLLLFFLGTISLSLCEEERGADEEEGDGEKLMKRGLFSILKGVGKIALKGLAKNMGKMGLDLVSCKISKEC
    

Molecular Weight8518.13 Da

Isoelectric Point (pI)8.49

Net Charge (pH 7.0)1.49

Net Charge (pH 7.4) 1.19

Charge Density (pH 7.0) 0.0190

GRAVY Index0.06

Hydrophobic Moment 0.64

Boman Index0.06

Instability Index29.94

Aliphatic Index 96.28

Aromaticity 0.0513

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3349.50

LogP -28.02

H-bond Donors 120.0

H-bond Acceptors 121.0

Rotatable Bonds 310.0

Heavy Atoms 590.0

Ring Count 4.0

Amide Bonds 78.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0031700 VERIFIED: YES

Provenance & Taxonomy

OrganismLithobates palustris [Animal]

FamilyFrog skin active peptide (FSAP); Esculentin subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetStaphylococcus aureus

RECORD: Rec_0036866 VERIFIED: YES