Peptide Database

Peptide NameBrevinin-2PRc

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Venom / Toxin ▸ General toxin ▸ Toxic

Standard StatusStandard

Sequence Length37 amino acids

Chemical FormulaC168H290N48O47S3

DescriptionStandard

        GLMSVLKGVLKTAGKHIFKNVGGSLLDQAKCKISGQC
    

Molecular Weight3830.59 Da

Isoelectric Point (pI)9.79

Net Charge (pH 7.0)4.82

Net Charge (pH 7.4) 4.53

Charge Density (pH 7.0) 0.1303

GRAVY Index0.21

Hydrophobic Moment 0.61

Boman Index0.12

Instability Index16.95

Aliphatic Index 102.70

Aromaticity 0.0270

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1543.21

LogP -16.20

H-bond Donors 55.0

H-bond Acceptors 56.0

Rotatable Bonds 137.0

Heavy Atoms 266.0

Ring Count 2.0

Amide Bonds 39.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0403335 VERIFIED: NO

Provenance & Taxonomy

OrganismRana pirica [Animal]

FamilyBrevinin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide31-37

Bio-Activity Profile

Function

Antimicrobial Antibacterial Hemolytic

TargetEscherichia coli, Pseudomonas aeruginosa, Enterobacter cloacae, Klebsiella pneumoniae, Staphylococcus aureus

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