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MYP_146277
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Basic Information
Brevinin-2PRc
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
37 amino acids
C168H290N48O47S3
Standard
Sequence
GLMSVLKGVLKTAGKHIFKNVGGSLLDQAKCKISGQC
Physicochemical Analysis
3830.59 Da
9.79
4.82
4.53
0.1303
0.21
0.61
0.12
16.95
102.70
0.0270
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1543.21
-16.20
55.0
56.0
137.0
266.0
2.0
39.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0036638 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Human erythrocytes
125 μM
HC50
Paperhttps://pubmed.ncbi.nlm.nih.gov/15003829/ PMID15003829 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15003829/
RECORD: Rec_0193470 VERIFIED: YES
Provenance & Taxonomy
Rana pirica [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
31-37
Bio-Activity Profile
Hemolytic Cytolytic
Erythrocytes
125.0 μM
HC50
PaperJ.M. Conlon et al. / Regulatory Peptides 118 (2004) 135-141. A family of brevinin-2 peptides with potent activity against Pseudomonas aeruginosa from the skin of the Hokkaido frog, Rana pirica
RECORD: Rec_0230735 VERIFIED: YES
Provenance & Taxonomy
Rana pirica [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
31-37
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
3.0 μM
MIC
PaperJ.M. Conlon et al. / Regulatory Peptides 118 (2004) 135-141. A family of brevinin-2 peptides with potent activity against Pseudomonas aeruginosa from the skin of the Hokkaido frog, Rana pirica
RECORD: Rec_0343812 VERIFIED: YES
Provenance & Taxonomy
Rana pirica [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
31-37
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
25.0 μM
MIC
PaperJ.M. Conlon et al. / Regulatory Peptides 118 (2004) 135-141. A family of brevinin-2 peptides with potent activity against Pseudomonas aeruginosa from the skin of the Hokkaido frog, Rana pirica
RECORD: Rec_0399463 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 59.5%, E 0.0%, T 27.0%, C 13.5% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Toxic Antimicrobial Hemolytic
PaperHemolytik: a database of experimentally determined hemolytic and non-hemolytic peptides PMID24174543 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24174543/
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