Peptide Database

Peptide NameSLAY-screened peptide P4841

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC118H170N30O32S

DescriptionStandard

        YICLPSTPGRWGRINYKDSYY
    

Molecular Weight2552.86 Da

Isoelectric Point (pI)9.05

Net Charge (pH 7.0)1.75

Net Charge (pH 7.4) 1.52

Charge Density (pH 7.0) 0.0832

GRAVY Index-0.81

Hydrophobic Moment 0.56

Boman Index-0.07

Instability Index74.42

Aliphatic Index 55.71

Aromaticity 0.2381

Extinction Coeff. Reduced 11460.00

Extinction Coeff. Oxidized 11460.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1015.35

LogP -7.67

H-bond Donors 38.0

H-bond Acceptors 35.0

Rotatable Bonds 75.0

Heavy Atoms 181.0

Ring Count 8.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0250445 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/